C₁₁H₈⁽¹⁸⁾FN

Base Information

• Chemical Name: C₁₁H₈⁽¹⁸⁾FN
• CAS No.: 1598371-26-6
• Molecular Formula: C₁₁H₈FN
• Molecular Weight: 172.191
• Mol file: 1598371-26-6.mol

Synonyms:C₁₁H₈⁽¹⁸⁾FN

Chemical Property of C₁₁H₈⁽¹⁸⁾FN

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₁H₈⁽¹⁸⁾FN

There total 3 articles about C₁₁H₈⁽¹⁸⁾FN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-5-phenylpyridine (66600-05-3) → C11H8(18)FN (1598371-26-6)

Guidance literature:

With Quinuclidine; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In water; dimethyl sulfoxide; at 200 ℃; for 0.5h; Reagent/catalyst; Temperature;

DOI:10.1002/ejoc.201700970

Reference yield:

iodobenzene (591-50-4) + 6-chloropyridin-3-ylboronic acid (444120-91-6) → C11H8(18)FN (1598371-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 80 °C / Inert atmosphere

2: [2.2.2]cryptande; Quinuclidine; [18F]fluoride ion, cyclotron produced, NCA / water; dimethyl sulfoxide / 0.5 h / 200 °C

With Quinuclidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In ethanol; water; dimethyl sulfoxide; toluene;

DOI:10.1002/ejoc.201700970

Reference yield:

→ C11H8(18)FN (1598371-26-6)

Guidance literature:

With potassium hydrogencarbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In water; dimethyl sulfoxide; acetonitrile; at 110 ℃; for 0.25h; Inert atmosphere;

upstream raw materials:

iodobenzene

6-chloropyridin-3-ylboronic acid

2-chloro-5-phenylpyridine