66600-05-3

Basic information

• Product Name: 2-CHLORO-5-PHENYLPYRIDINE
• Synonyms: 2-CHLORO-5-PHENYLPYRIDINE;6-Chloro-3-phenylpyridine;Pyridine, 2-chloro-5-phenyl-
• CAS NO: 66600-05-3
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64
• Mol File: 66600-05-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 65-66 °C
• Boiling Point: 312.7°C at 760 mmHg
• Flash Point: 172°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 0.000958mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• PKA: -0.37±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-PHENYLPYRIDINE(66600-05-3)
• EPA Substance Registry System: 2-CHLORO-5-PHENYLPYRIDINE(66600-05-3)

Safety Data

• Hazardous Substances Data: 66600-05-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-phenylpyridine is a chemical compound with the molecular formula C11H8ClN. It is a pyridine derivative that contains a chlorine atom at position 2 and a phenyl group at position 5 on the pyridine ring. 2-CHLORO-5-PHENYLPYRIDINE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It is also utilized as an intermediate in the production of diverse chemical products. 2-Chloro-5-phenylpyridine is considered to be a hazardous substance and should be handled with care due to its potential health and environmental risks.

InChI:InChI=1/C11H8ClN/c12-11-7-6-10(8-13-11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 69045-79-0 2-choro-5-iodopyridine 
• 13471-35-7 dimethyl phenylboronate 
• 53939-30-3 5-bromo-2-chloropyridine 
• 2633-57-0 triallyl(phenyl)silane 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 444120-91-6 6-chloropyridin-3-ylboronic acid 
• 108-90-7 chlorobenzene 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 75754-04-0 5-phenyl-pyridine-2-carboxylic acid 
• 28557-00-8 phenylzinc chloride 
• 591-50-4 iodobenzene 
• 41288-96-4 6-chloropyridine-3-ol 

Downstream Products

• 718639-25-9 2-[(5-phenylpyridin-2-yl)amino]ethanol 
• 1391736-85-8 C₁₇H₁₅N₃OS₂ 
• 1391736-87-0 C₁₈H₁₇N₃OS₂ 
• 149530-82-5 C₁₁H₉NS 
• 1598371-26-6 C₁₁H₈⁽¹⁸⁾FN 
• 1462903-92-9 2-(2-methoxyphenyl)-5-phenylpyridine 
• 1609368-44-6 C₄₅H₃₄IrN₄O 
• 1609374-17-5 2-methyl-8-(5-phenylpyridin-2-yl)benzofuro[2,3-b]pyridine 
• 1610362-85-0 2-(3-aminopropylamino)-5-phenylpyridine 1-oxide hydrochloride 
• 76066-38-1 2-hydrazinyl-5-phenylpyridine 
• 33421-40-8 5-phenyl-pyridin-2-ylamine 
• 120281-56-3 2-iodo-5-phenyl-pyridine 
• 107351-86-0 N²-methyl-5-phenylpyridine-2,3-diamine 
• 107351-85-9 2-methylamino-3-bromo-5-phenylpyridine 

Relevant articles and documents

Method for preparing 2-chloro-5-substituted pyridine

The invention belongs to the technical field of chemical synthesis of pesticides, and particularly relates to a method for preparing 2-chloro-5-substituted pyridine, in particular to a method for preparing 2-chloro-5-methylpyridine. The method comprises the following steps: reacting amide as shown in a formula C which is used as a raw material in the presence of a chlorinating agent and N, N-dimethylformamide, and distilling after the reaction is finished to obtain the 5-substituted 2-chloropyridine as shown in a formula I which is described in the specification. When the 5-substituted 2-chloropyridine is prepared from the compound with the structure shown in the formula C, the by-product is allyl chloride (or homologues thereof) with small molecular weight, the boiling point of the by-product is obviously different from that of the product, the reaction conversion rate and the yield are higher than those of the prior art, the by-product is easy to separate from the product, and the by-product is more beneficial to recovery; therefore, according to the preparation method, the equipment investment can be greatly saved, the production cost is reduced, and the operation procedure is simplified; and in the route, the amine with lower price is used as a starting raw material, so that the production cost is reduced.

Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.

Collagen

PROBLEM TO BE SOLVED: To provide a collagen producing promoter preferable for preventing or improving wrinkle formation.SOLUTION: There is provided a collagen producing promoter made of a compound expressed by the following general formula and an external