N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Base Information

Chemical Name:N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide
CAS No.:200400-59-5
Molecular Formula:C₂₆H₂₉N₃O₃
Molecular Weight:431.535
Hs Code.:

Synonyms:N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

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Chemical Property of N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

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Technology Process of N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

There total 15 articles about N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 200400-51-7
(4S)-N-(4-cyclohexylbutyl)-4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

: 200400-59-5
N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: With nickel(IV) oxide; 4 A molecular sieve; In 1,4-dioxane; benzene; for 4h; Heating;
DOI:10.1021/jm980173n

Reference yield:

: 89667-30-1
methyl 4-(3-pyridylcarbonyl)benzoate

: 200400-59-5
N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.0N aq. NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

2: 65 percent / HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

3: 75 percent / PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

4: 74 percent / NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; nickel(IV) oxide; sodium hydroxide; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm980173n

Reference yield:

: 200400-36-8
4-(3-pyridylcarbonyl)benzoic acid

: 200400-59-5
N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

2: 75 percent / PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

3: 74 percent / NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; nickel(IV) oxide; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm980173n