N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Base Information

• Chemical Name: N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide
• CAS No.: 200400-59-5
• Molecular Formula: C₂₆H₂₉N₃O₃
• Molecular Weight: 431.535
• Mol file: 200400-59-5.mol

Synonyms:N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Chemical Property of N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

There total 15 articles about N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(4S)-N-(4-cyclohexylbutyl)-4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide (200400-51-7) → N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide (200400-59-5)

Guidance literature:

With nickel(IV) oxide; 4 A molecular sieve; In 1,4-dioxane; benzene; for 4h; Heating;

DOI:10.1021/jm980173n

Reference yield:

methyl 4-(3-pyridylcarbonyl)benzoate (89667-30-1) → N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide (200400-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.0N aq. NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

2: 65 percent / HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

3: 75 percent / PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

4: 74 percent / NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; nickel(IV) oxide; sodium hydroxide; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm980173n

Reference yield:

4-(3-pyridylcarbonyl)benzoic acid (200400-36-8) → N-(4-cyclohexylbutyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide (200400-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

2: 75 percent / PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

3: 74 percent / NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; nickel(IV) oxide; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm980173n

upstream raw materials:

4-cyclohexyl-butylamine

2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylic acid

(4S)-N-(4-cyclohexylbutyl)-4,5-dihydro-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

3-Bromopyridine

Downstream raw materials:

(Z)-7-<4-<4-<<(4-cyclohexylbutyl)amino>carbonyl>-2-oxazolyl>phenyl>-7-(3-pyridyl)hept-6-enoic acid

(E)-7-[4-[4-[[(4-cyclohexylbutyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(pyridin-3-yl)hept-6-enoic acid