2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide

Base Information

• Chemical Name: 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide
• CAS No.: 1567836-85-4
• Molecular Formula: C₂₄H₁₇F₂N₃O₄S₂
• Molecular Weight: 513.545
• Mol file: 1567836-85-4.mol

Synonyms:2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide

Chemical Property of 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide

There total 2 articles about 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide (1083326-73-1) + 5-(5-bromothiophen-2-yl)isoindolin-1-one (1567836-84-3) → 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide (1567836-85-4)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; at 105 ℃; for 16h; Inert atmosphere;

Reference yield:

5-iodoisoindolin-1-one (897958-99-5) → 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide (1567836-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / Reflux; Inert atmosphere

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol; toluene / 16 h / 105 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene;

upstream raw materials:

5-iodoisoindolin-1-one

N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

5-(5-bromothiophen-2-yl)isoindolin-1-one