Chemical Property of 4-Amino-1,8-naphthalimide
Chemical Property:
- Appearance/Colour:orange amorphous powder
- Vapor Pressure:6.75E-12mmHg at 25°C
- Melting Point:360 °C
- Refractive Index:1.764
- Boiling Point:544.1 °C at 760 mmHg
- PKA:9.53±0.20(Predicted)
- Flash Point:282.8 °C
- PSA：75.95000
- Density:1.474 g/cm3
- LogP:1.64270
- Storage Temp.:−20°C
- Solubility.:Soluble in DMSO
- Water Solubility.:354mg/L at 25℃
- XLogP3:1.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:0
- Exact Mass:212.058577502
- Heavy Atom Count:16
- Complexity:342
- Purity/Quality:
-
99.9% *data from raw suppliers
4-Amino-1,8-naphthalimide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N
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Description
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.
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Uses
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.
