H₂N-L-Val-L-Phe-Bu

Base Information

• Chemical Name: H₂N-L-Val-L-Phe-Bu
• CAS No.: 264887-19-6
• Molecular Formula: C₁₈H₂₉N₃O₂
• Molecular Weight: 319.447
• Mol file: 264887-19-6.mol

Synonyms:H₂N-L-Val-L-Phe-Bu

Chemical Property of H₂N-L-Val-L-Phe-Bu

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H₂N-L-Val-L-Phe-Bu

There total 11 articles about H₂N-L-Val-L-Phe-Bu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-valyl-L-phenylalanine n-butylamide (264887-79-8) → H2N-L-Val-L-Phe-Bu (264887-19-6)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; at 25 ℃; for 3h; under 1551.49 Torr;

DOI:10.1021/jm990226g

Reference yield:

[(S)-1-((S)-1-Butylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester (329324-40-5) → H2N-L-Val-L-Phe-Bu (264887-19-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 22 ℃; for 1h;

DOI:10.1021/ja0118744

Reference yield:

t-Boc-L-valine (13734-41-3) + (S)-2-amino-N-butyl-3-phenylpropionamide (35373-95-6) → H2N-L-Val-L-Phe-Bu (264887-19-6)

Guidance literature:

t-Boc-L-valine; (S)-2-amino-N-butyl-3-phenylpropionamide; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 22 ℃; for 4h;

With trifluoroacetic acid; at 0 - 22 ℃; for 0.666667h; Further stages.;

DOI:10.1021/ja003698p

upstream raw materials:

N-benzyloxycarbonyl-L-valyl-L-phenylalanine n-butylamide

[(S)-1-((S)-1-Butylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester

t-Boc-L-valine

(S)-2-amino-N-butyl-3-phenylpropionamide

Downstream raw materials:

N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide