(3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

Base Information

Chemical Name:(3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride
CAS No.:914988-75-3
Molecular Formula:C₁₄H₂₀ClFN₂S*ClH
Molecular Weight:339.305
Hs Code.:

Synonyms:(3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

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Chemical Property of (3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

Chemical Property:

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Technology Process of (3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

There total 4 articles about (3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60811-21-4
1-bromo-3-chloro-4-fluorobenzene

: 914988-75-3
(3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / Heating / reflux

2.1: acetic acid / 20 °C

2.2: 15 h / 20 °C

3.1: hydrogenchloride / ethanol / 1 h / Heating / reflux

3.2: 15 h / 20 °C

With hydrogenchloride; acetic acid; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; toluene;

Reference yield:

: C₁₉H₂₈ClFN₂O₂S

: 914988-75-3
(3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

Guidance literature:: C₁₉H₂₈ClFN₂O₂S; With hydrogenchloride; In ethanol; for 1h; Heating / reflux;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 15h;

Reference yield:

: 156150-67-3
3-chloro-4-fluoroiodobenzene

: 914988-75-3
(3-chloro-4-fluorophenyl)-(3-methylsulfanylpropyl)-(S)-pyrrolidin-3-ylamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; ethylene glycol / copper(l) iodide / 46 h / Heating / reflux

2.1: acetic acid / 20 °C

2.2: 15 h / 20 °C

3.1: hydrogenchloride / ethanol / 1 h / Heating / reflux

3.2: 15 h / 20 °C

With hydrogenchloride; potassium phosphate; ethylene glycol; acetic acid; copper(l) iodide; In ethanol;