2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Base Information

• Chemical Name: 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one
• CAS No.: 1335015-70-7
• Molecular Formula: C₂₅H₂₁FN₄O₄S
• Molecular Weight: 492.531
• Mol file: 1335015-70-7.mol

Synonyms:2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Chemical Property of 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

There total 6 articles about 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + 2-(4-(piperazine-1-carbonyl)phenyl) quinazolin-4(3H)-one (1335014-09-9) → 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one (1335015-70-7)

Guidance literature:

2-(4-(piperazine-1-carbonyl)phenyl) quinazolin-4(3H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 100 ℃;

4-Fluorobenzenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 100 ℃; for 16h;

DOI:10.1016/j.ejmech.2011.05.061

Reference yield:

4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoic acid (374711-37-2) → 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one (1335015-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; chloroform / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 100 °C

3.2: 16 h / 100 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.ejmech.2011.05.061

Reference yield:

tert-butyl 4-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoyl)piperazine-1-carboxylate (1335014-00-0) → 2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one (1335015-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; chloroform / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 100 °C

2.2: 16 h / 100 °C

With hydrogenchloride; sodium hydride; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.ejmech.2011.05.061

upstream raw materials:

4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoic acid

tert-butyl 4-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoyl)piperazine-1-carboxylate

4-(2-carbamoylphenylcarbamoyl)benzoic acid methyl ester

4-Fluorobenzenesulfonyl chloride