{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

Base Information

Chemical Name:{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol
CAS No.:145801-30-5
Molecular Formula:C₂₇H₃₂N₂O₄S
Molecular Weight:480.628
Hs Code.:

Synonyms:{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

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Chemical Property of {(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

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Technology Process of {(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

There total 4 articles about {(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

: 145801-29-2
Acetic acid (1S,4R,5S)-4-[1-(4-methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-ylmethyl ester

: 145801-30-5
{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

Guidance literature:: With potassium hydroxide; In ethanol; at 25 ℃; for 20h;
DOI:10.1016/0957-4166(92)80018-R

Reference yield:

: 20-phenylsulfinyl-(N⁽¹⁾-p-methoxyphenylsulfonyl)hobartine

: 145801-30-5
{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 28.3 percent / P(OMe)3 / toluene / 18 h / 110 °C

2: 89.4 percent / TFA, SOCl₂ / CH₂Cl₂ / 15 h / Ambient temperature

3: 68.1 percent / 1.) HOAc, 2.) KOAc, dicyclohexyl-18-crown-6 / acetonitrile / 1.) 25 deg C, 5 min, 2.) 40 deg C, 13 h

4: 92.2 percent / 0.5 M KOH / ethanol / 20 h / 25 °C

With perhydrodibenzo-18-crown-6; potassium hydroxide; thionyl chloride; potassium acetate; acetic acid; trifluoroacetic acid; phosphorous acid trimethyl ester; In ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/0957-4166(92)80018-R

Reference yield:

: 145801-28-1
(1S,4R,5S)-6-Chloromethyl-4-[1-(4-methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-ene

: 145801-30-5
{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 68.1 percent / 1.) HOAc, 2.) KOAc, dicyclohexyl-18-crown-6 / acetonitrile / 1.) 25 deg C, 5 min, 2.) 40 deg C, 13 h

2: 92.2 percent / 0.5 M KOH / ethanol / 20 h / 25 °C

With perhydrodibenzo-18-crown-6; potassium hydroxide; potassium acetate; acetic acid; In ethanol; acetonitrile;
DOI:10.1016/0957-4166(92)80018-R