(1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol

Base Information

• Chemical Name: (1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol
• CAS No.: 145801-26-9
• Molecular Formula: C₂₇H₃₂N₂O₄S
• Molecular Weight: 480.628

Synonyms:(1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol

Chemical Property of (1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol

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Technology Process of (1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol

There total 2 articles about (1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

20-phenylsulfinyl-(N(1)-p-methoxyphenylsulfonyl)hobartine → (1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol (145801-26-9)

Guidance literature:

With piperidine; In ethanol; at 70 ℃; for 24h;

DOI:10.1016/0957-4166(92)80018-R

Reference yield: 28.3%

20-phenylsulfinyl-(N(1)-p-methoxyphenylsulfonyl)hobartine → (N(1)-p-methoxyphenylsulfonyl)aristofruticosine + (1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol (145801-26-9) + (1R,4R,5S,7S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol (145842-72-4)

Guidance literature:

With phosphorous acid trimethyl ester; In toluene; at 110 ℃; for 18h;

DOI:10.1016/0957-4166(92)80018-R

Reference yield: 87.0%

(1R,4R,5S,7R)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-6-methylene-3-aza-bicyclo[3.3.1]nonan-7-ol (145801-26-9) → (N(1)-p-methoxyphenylsulfonyl)aristofruticosine

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; 1.) 0 deg C, 2 h, 2.) 25 deg C, 24 h;

DOI:10.1016/0957-4166(92)80018-R

Downstream raw materials:

(1S,4R,5S)-6-Chloromethyl-4-[1-(4-methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-ene

1-[(4-methoxyphenyl)sulfonyl]hobartine

(1S,2R,5R)-2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-4,4-dimethyl-8-methylene-3-aza-bicyclo[3.3.1]non-6-ene

{(1S,4R,5S)-4-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-3-aza-bicyclo[3.3.1]non-6-en-6-yl}-methanol

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