2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Base Information

Chemical Name:2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester
CAS No.:912296-81-2
Molecular Formula:C₃₁H₂₅NO₇
Molecular Weight:523.542
Hs Code.:

Synonyms:2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

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Chemical Property of 2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

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Technology Process of 2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

There total 7 articles about 2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 912296-80-1
2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

: 912296-81-2
2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2006.06.023

Reference yield:

: 912296-82-3
3-(benzyloxycarbonyl)phenyl chloroformate

: 912296-81-2
2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 43 percent / tetrahydrofuran; hexane / 3 h / 20 °C

2.1: 87 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 20 °C

With trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2006.06.023

Reference yield:

: {[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-acetic acid benzyl ester

: 912296-81-2
2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaBH₃CN; AcOH

2.1: 2.30 g / triethylamine / CH₂Cl₂ / 2 h

3.1: LiHMDS / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 43 percent / tetrahydrofuran; hexane / 3 h / 20 °C

4.1: 87 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2006.06.023