2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Base Information

• Chemical Name: 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester
• CAS No.: 912296-80-1
• Molecular Formula: C₄₀H₃₅NO₉
• Molecular Weight: 673.719
• Mol file: 912296-80-1.mol

Synonyms:2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Chemical Property of 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester

There total 6 articles about 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-(benzyloxycarbonyl)phenyl chloroformate (912296-82-3) + N-benzoyl-N-(2,4-dimethoxybenzyl)glycine benzyl ester (912296-79-8) → 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester (912296-80-1)

Guidance literature:

N-benzoyl-N-(2,4-dimethoxybenzyl)glycine benzyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

3-(benzyloxycarbonyl)phenyl chloroformate; In tetrahydrofuran; hexane; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2006.06.023

Reference yield:

{[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-acetic acid benzyl ester → 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester (912296-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaBH₃CN; AcOH

2.1: 2.30 g / triethylamine / CH₂Cl₂ / 2 h

3.1: LiHMDS / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 43 percent / tetrahydrofuran; hexane / 3 h / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.bmc.2006.06.023

Reference yield:

Gly-OBz (1738-68-7) → 2-[benzoyl(2,4-dimethoxybenzyl)amino]malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester (912296-80-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium acetate; AcOH / 0.5 h / 20 °C

2.1: NaBH₃CN; AcOH

3.1: 2.30 g / triethylamine / CH₂Cl₂ / 2 h

4.1: LiHMDS / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 43 percent / tetrahydrofuran; hexane / 3 h / 20 °C

With sodium acetate; sodium cyanoborohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.bmc.2006.06.023

upstream raw materials:

3-(benzyloxycarbonyl)phenyl chloroformate

N-benzoyl-N-(2,4-dimethoxybenzyl)glycine benzyl ester

Gly-OBz

3-Benzyloxycarbonyl-phenol

Downstream raw materials:

2-(benzoylamino)malonic acid benzyl ester 3-(benzyloxycarbonyl)phenyl ester