1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

Base Information

• Chemical Name: 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone
• CAS No.: 150308-12-6
• Molecular Formula: C₁₈H₁₆BrNO₃
• Molecular Weight: 374.234

Synonyms:1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

Chemical Property of 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

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Technology Process of 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

There total 1 articles about 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(p-Methoxyphenyl)-2-methyl-3-acetyl-5-oxyindole (5546-17-8) → 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone (150308-12-6)

Guidance literature:

With bromine; In acetic acid; for 2h; Ambient temperature;

Reference yield: 74.7%

allyl bromide (106-95-6) + 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone (150308-12-6) → 1-[5-Allyloxy-6-bromo-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

Guidance literature:

With potassium carbonate; In acetone; for 25h; Heating;

Reference yield: 74.0%

chloroacetic acid ethyl ester (105-39-5) + 1-[6-Bromo-5-hydroxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone (150308-12-6) → [3-Acetyl-6-bromo-1-(4-methoxy-phenyl)-2-methyl-1H-indol-5-yloxy]-acetic acid ethyl ester (157064-72-7)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 50h; Heating;

upstream raw materials:

1-(p-Methoxyphenyl)-2-methyl-3-acetyl-5-oxyindole

Downstream raw materials:

2-[3-Acetyl-6-bromo-1-(4-methoxy-phenyl)-2-methyl-1H-indol-5-yloxy]-1-phenyl-ethanone

[3-Acetyl-6-bromo-1-(4-methoxy-phenyl)-2-methyl-1H-indol-5-yloxy]-acetic acid ethyl ester

1-[6-Bromo-5-methoxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

2-Bromo-1-[6-bromo-5-methoxy-1-(4-methoxy-phenyl)-2-methyl-1H-indol-3-yl]-ethanone

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