<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

Base Information

Chemical Name:<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide
CAS No.:164365-94-0
Molecular Formula:C₃₆H₅₉N₃O₆
Molecular Weight:629.881
Hs Code.:

<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-<N-(benzyloxy)carbonyl>piperidyl>-9-undecenamide

Synonyms:<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

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Chemical Property of <11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

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Technology Process of <11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

There total 14 articles about <11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 164365-93-9
<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-<3-<(tert-butyldimethylsilyl)oxy>propyl>-11-<2-piperidyl>-9-undecenamide

: 164365-94-0
<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;
DOI:10.1039/c39950001015

Reference yield:

: 34418-91-2
2,3,4,5-tetrahydropyridine N-oxide

: 164365-94-0
<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

Guidance literature:: Multi-step reaction with 9 steps

1: 69 percent / toluene / 14 h / Heating

2: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 45 °C

3: 91 percent / H₂, PdCl₂ / methanol / 37 h / 4940 Torr

4: 85 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 14 h / Ambient temperature

5: 84 percent / HIO₄ / tetrahydrofuran; H₂O / 2 h / 0 °C

6: 56 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h / 0 °C

7: 96 percent / aq. KOH / methanol / 5 h / Ambient temperature

8: 95 percent / (EtO)2P(O)CN, Et₃N / dimethylformamide / 14 h / Ambient temperature

9: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature

With potassium hydroxide; diethyl cyanophosphonate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; periodic acid; triethylamine; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo9518258

Reference yield:

: 173425-05-3
<2R,2(1S),3aS>-2-(1-hydroxy-2-methylpropyl)-3,3a,4,5,6,7-hexahydro-2H-isoxazolo<2,3-a>pyridine

: 164365-94-0
<11(2S)>-N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)-11-<2-piperidyl>-9-undecenamide

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / H₂, PdCl₂ / methanol / 37 h / 4940 Torr

2: 85 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 14 h / Ambient temperature

3: 84 percent / HIO₄ / tetrahydrofuran; H₂O / 2 h / 0 °C

4: 56 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h / 0 °C

5: 96 percent / aq. KOH / methanol / 5 h / Ambient temperature

6: 95 percent / (EtO)2P(O)CN, Et₃N / dimethylformamide / 14 h / Ambient temperature

7: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature

With potassium hydroxide; diethyl cyanophosphonate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; periodic acid; triethylamine; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo9518258