2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

Base Information

Chemical Name:2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate
CAS No.:1403884-48-9
Molecular Formula:C₂₆H₁₅BrF₅N₃O₈
Molecular Weight:672.316
Hs Code.:

Synonyms:2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

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Chemical Property of 2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

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Technology Process of 2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

There total 6 articles about 2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403880-91-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

: 7693-46-1
4-Nitrophenyl chloroformate

: 1403884-48-9
2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403884-48-9
2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 130 °C

2: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

4: N-Bromosuccinimide; acetic acid / 20 °C

5: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7: potassium carbonate / methanol / 1 h / 20 °C

8: pyridine / dichloromethane / 2 h / 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; triethylamine; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1403883-97-5
2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403884-48-9
2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 1 h / 20 °C

5: pyridine / dichloromethane / 2 h / 20 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;