tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate
• CAS No.: 1330626-14-6
• Molecular Formula: C₁₁H₁₂BrN₃O₂
• Molecular Weight: 298.139
• Mol file: 1330626-14-6.mol

Synonyms:tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate

Chemical Property of tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate

There total 1 articles about tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-pyrazolo-[4,3-b]-pyridine (272-52-6) → tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate (1330626-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; bromine / water / 3 h / 20 °C

2: dmap; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With dmap; bromine; triethylamine; sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate (1330626-14-6) + 3-chloro-aniline (108-42-9) → tert-butyl 3-((3-chlorophenyl)amino)-1H-pyrazolo[4,3-b]pyridine-1-carboxylate (1330626-15-7)

Guidance literature:

With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) + tert-butyl 3-bromo-1H-pyrazolo[4,3-b]pyridine-1-carboxylate (1330626-14-6) → C17H16ClFN4O2

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acschemneuro.6b00035

upstream raw materials:

1H-pyrazolo-[4,3-b]-pyridine

Downstream raw materials:

tert-butyl 3-((3-chlorophenyl)amino)-1H-pyrazolo[4,3-b]pyridine-1-carboxylate

N-(3-chlorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine