benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Base Information

Chemical Name:benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate
CAS No.:1450620-30-0
Molecular Formula:C₂₂H₂₃N₃O₃
Molecular Weight:377.443
Hs Code.:

Synonyms:benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Suppliers and Price of benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

There total 5 articles about benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84331-14-6
5-Acetyl-2-fluoropyridine

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 1450620-30-0
benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 140 ℃; for 72h;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1450620-30-0
benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / water; 1,4-dioxane / 2.33 h / 20 °C

2.1: triethylamine; dmap / dichloromethane / 1 h / 20 °C

3.1: tetrahydrofuran / 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0.25 h / -10 - 20 °C

4.2: 2.17 h

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 140 °C

With dmap; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1228675-25-9
2-oxopiperazine-1,4-dicarboxylic acid 1-tert-butyl ester 4-benzyl ester

: 1450620-30-0
benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / -10 - 20 °C

2.2: 2.17 h

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 140 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;