84331-14-6

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethanone, 1-(6-fluoro-3-pyridinyl)(9CI) is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Synthesis:
Ethanone, 1-(6-fluoro-3-pyridinyl)(9CI) also serves as an important building block in the creation of agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Research and Development:
Ethanone, 1-(6-fluoro-3-pyridinyl)(9CI) is employed in research and development within the fields of organic chemistry and medicinal chemistry. Its properties and potential uses are being explored to advance scientific understanding and innovation in these areas.
Used in Organic Chemistry:
In the realm of organic chemistry, Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) is used as a reagent or starting material for various chemical reactions, enabling the synthesis of complex organic molecules with specific properties and functions.
Used in Medicinal Chemistry:
Ethanone, 1-(6-fluoro-3-pyridinyl)(9CI) is also utilized in medicinal chemistry for the design and synthesis of novel bioactive molecules. Its incorporation into drug candidates can potentially lead to the discovery of new therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C7H6FNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3

Upstream product

• 766-11-0 5-bromo-2-fluoropyridine 
• 1034467-37-2 1-(6-fluoropyridin-3-yl)ethan-1-ol 
• 403-45-2 6-fluoronicotinic acid 
• 75-16-1 methylmagnesium bromide 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 774239-06-4 6-fluoro-N-methoxy-N-methylpyridine-3-carboxamide 

Downstream Products

• 1395039-12-9 1-(6-isopropoxypyridin-3-yl)ethan-1-one 
• 59229-45-7 1-(6-phenoxypyridine-3-yl)ethan-1-one 
• 1450620-30-0 benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate 

Relevant academic research and scientific papers

Modular Synthesis of Alkenyl Sulfamates and β-Ketosulfonamides via Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry and Photomediated 1,3-Rearrangement

Herein, we report a synthesis of medicinally relevant β-ketosulfonamides via a photomediated 1,3-rearrangement of alkenyl sulfamates. This protocol tolerates a wide array of sensitive functional groups including alkenes, alkynes, and nitrogen-based heterocycles. Additionally, this work provides a general approach toward alkenyl sulfamates via a two-step Sulfur(VI) Fluoride Exchange (SuFEx) sequence capitalizing on SO2F2 as a linchpin to efficiently couple readily available ketones and amines without a large excess of either partner.

Nucleophilic Fluorination of Heteroaryl Chlorides and Aryl Triflates Enabled by Cooperative Catalysis

Aryl and heteroaryl fluorides are growing to be dominant motifs in pharmaceuticals and agrochemicals, yet they are rare in both nature and commodity chemicals. As a consequence, there is an increasingly urgent need to develop mild, cost-effective, and scalable methods for fluorination. The most straightforward route to synthesize aryl fluorides is through the halide exchange "halex"reaction, but conditions, cost, and atom economy preclude most available methods from large-scale manufacturing processes. We report a new approach that leverages the cooperative action of 18-crown-6 ether and tetramethylammonium chloride to catalytically access the reactivity of tetramethylammonium fluoride and achieve halex fluorinations under mild conditions with operational ease. The described methodology readily converts both heteroaryl chlorides and aryl triflates to their corresponding (hetero)aryl fluorides in high yields and purities.

BTK INHIBITOR

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

Asymmetric Biocatalytic Synthesis of Fluorinated Pyridines through Transesterification or Transamination: Computational Insights into the Reactivity of Transaminases

The synthesis of a family of pyridines bearing a fluorinated substituent on the aromatic ring has been carried out through two independent and highly stereoselective chemoenzymatic strategies. Short chemical synthetic routes toward fluorinated racemic amines and prochiral ketones have been developed, which served as substrates to explore the suitability of lipases and transaminases in asymmetric biotransformations. The lipase-catalyzed kinetic resolution via acylation of racemic amines proceeded smoothly giving conversions close to 50% and excellent enantioselectivities. Alternatively, the biotransamination of the corresponding prochiral ketones was investigated giving access to both optically pure amine enantiomers using transaminases with complementary selectivity. High to quantitative conversion values were achieved, which allowed the isolation of the amines in moderate to high yields (40–88%). A deeper understanding of the latter process was enabled by performing theoretical calculations on thermodynamic and mechanistic aspects. Calculations showed that the biotransamination reactions are highly favoured by the presence of fluorine atoms and the pyridine ring. (Figure presented.).

PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.

ARALKYLAMINOETHANOL HETEROCYCLIC COMPOUNDS

Heterocyclic aminoethanols of the formula: Het--CHOH--CH 2--NH-aralkylwhere Het is a 6-10 membered N-heterocycle are disclosed. The compounds are useful as pharmaceuticals.