(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

Base Information

Chemical Name:(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene
CAS No.:1414861-32-7
Molecular Formula:C₁₃H₁₇IO₃
Molecular Weight:348.181
Hs Code.:

Synonyms:(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

Suppliers and Price of (E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

Chemical Property:

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Technology Process of (E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

There total 5 articles about (E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 6117-91-5,542-72-3
(E/Z)-2-buten-1-ol

: 1414861-31-6
5-iodo-2-(methoxymethoxy)-3-methylphenol

: 1414861-32-7
(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 19h; Inert atmosphere;
DOI:10.1055/s-0032-1316643

Reference yield:

: 488-17-5
3-methylbenzene-1,2-diol

: 1414861-32-7
(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2: acetic acid / 16 h / 70 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane; acetic acid methyl ester / 18.5 h / 0 - 20 °C / Inert atmosphere

4: water; sodium hydroxide / ethanol / 5 h / Inert atmosphere; Reflux

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; water; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid methyl ester;
DOI:10.1055/s-0032-1316643

Reference yield:

: 244126-22-5
toluene-4-sulfonic acid 2-hydroxy-3-methyl-phenyl ester

: 1414861-32-7
(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 16 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane; acetic acid methyl ester / 18.5 h / 0 - 20 °C / Inert atmosphere

3: water; sodium hydroxide / ethanol / 5 h / Inert atmosphere; Reflux

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; water; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid methyl ester;
DOI:10.1055/s-0032-1316643