Technology Process of Carbamic acid (Z)-(4R,5R)-5-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-2-[(Z)-4-methoxy-benzenesulfonylimino]-2,3,4,5,8,9-hexahydro-1H-[1,3]diazonin-4-ylmethyl ester
There total 13 articles about Carbamic acid (Z)-(4R,5R)-5-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-2-[(Z)-4-methoxy-benzenesulfonylimino]-2,3,4,5,8,9-hexahydro-1H-[1,3]diazonin-4-ylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C23H30N6O7S2; Trichloroacetyl isocyanate;
In
tetrahydrofuran; acetonitrile;
at -78 ℃;
With
potassium carbonate;
In
methanol;
DOI:10.1021/ja0608545
- Guidance literature:
-
Multi-step reaction with 13 steps
1.1: H2 / Pd/CaCO3/Pb / tetrahydrofuran
2.1: NaN3; nBu4NI / dimethylformamide
3.1: 85 percent / nBu4NI; K2CO3 / acetonitrile
4.1: Me3P; H2O / tetrahydrofuran
5.1: iPr2NEt / acetonitrile
6.1: pyridine; DMAP / CH2Cl2
7.1: NaN3 / dimethylformamide / -15 °C
8.1: 74 percent / (NH4)2Ce(NO3)6 / CH2Cl2; 2-methyl-propan-2-ol
9.1: tBuOK
9.2: 70 percent / (Me3Si)2NH
10.1: 95 percent / H2O / acetonitrile / 70 °C
11.1: Me3P; H2O / tetrahydrofuran
12.1: AgNO3; Et3N / acetonitrile
13.1: tetrahydrofuran; acetonitrile / -78 °C
13.2: 82 percent / K2CO3 / methanol
With
pyridine; dmap; sodium azide; ammonium cerium(IV) nitrate; potassium tert-butylate; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane;
Lindlar's catalyst;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja0608545
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 85 percent / nBu4NI; K2CO3 / acetonitrile
2.1: Me3P; H2O / tetrahydrofuran
3.1: iPr2NEt / acetonitrile
4.1: pyridine; DMAP / CH2Cl2
5.1: NaN3 / dimethylformamide / -15 °C
6.1: 74 percent / (NH4)2Ce(NO3)6 / CH2Cl2; 2-methyl-propan-2-ol
7.1: tBuOK
7.2: 70 percent / (Me3Si)2NH
8.1: 95 percent / H2O / acetonitrile / 70 °C
9.1: Me3P; H2O / tetrahydrofuran
10.1: AgNO3; Et3N / acetonitrile
11.1: tetrahydrofuran; acetonitrile / -78 °C
11.2: 82 percent / K2CO3 / methanol
With
pyridine; dmap; sodium azide; ammonium cerium(IV) nitrate; potassium tert-butylate; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja0608545
