Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

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Chemical Name:Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester
CAS No.:884335-15-3
Molecular Formula:C₂₄H₃₁N₇O₁₀S₂
Molecular Weight:641.683
Hs Code.:

Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

Synonyms:Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

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Chemical Property of Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

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Technology Process of Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

There total 15 articles about Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 884335-13-1
Carbamic acid (Z)-(4R,5R)-5-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-2-[(Z)-4-methoxy-benzenesulfonylimino]-2,3,4,5,8,9-hexahydro-1H-[1,3]diazonin-4-ylmethyl ester

: 884335-15-3
Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

Guidance literature:: With osmium (III) chloride; sodium carbonate; In water; ethyl acetate; acetonitrile;
DOI:10.1021/ja0608545

Reference yield:

: 884335-03-9
Toluene-4-sulfonic acid 4-((4R,5S)-5-hydroxy-2,2-dioxo-2λ⁶-[1,2,3]oxathiazinan-4-yl)-but-3-ynyl ester

: 884335-15-3
Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: H₂ / Pd/CaCO₃/Pb / tetrahydrofuran

2.1: NaN₃; nBu₄NI / dimethylformamide

3.1: 85 percent / nBu₄NI; K₂CO₃ / acetonitrile

4.1: Me₃P; H₂O / tetrahydrofuran

5.1: iPr₂NEt / acetonitrile

6.1: pyridine; DMAP / CH₂Cl₂

7.1: NaN₃ / dimethylformamide / -15 °C

8.1: 74 percent / (NH₄)2Ce(NO₃)6 / CH₂Cl₂; 2-methyl-propan-2-ol

9.1: tBuOK

9.2: 70 percent / (Me₃Si)2NH

10.1: 95 percent / H₂O / acetonitrile / 70 °C

11.1: Me₃P; H₂O / tetrahydrofuran

12.1: AgNO₃; Et₃N / acetonitrile

13.1: tetrahydrofuran; acetonitrile / -78 °C

13.2: 82 percent / K₂CO₃ / methanol

14.1: 57 percent / OsCl₃; Na₂CO₃ / ethyl acetate; acetonitrile; H₂O

With pyridine; dmap; sodium azide; ammonium cerium(IV) nitrate; osmium (III) chloride; potassium tert-butylate; water; hydrogen; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja0608545

Reference yield:

: 884335-17-5
(4R,5S)-4-((Z)-4-Azido-but-1-enyl)-2,2-dioxo-2λ⁶-[1,2,3]oxathiazinan-5-ol

: 884335-15-3
Carbamic acid (3R,4S,4aR,5S)-4-({amino-[(E)-4-methoxy-benzenesulfonylimino]-methyl}-amino)-4a,5-dihydroxy-1-[(E)-4-methoxy-benzenesulfonylimino]-octahydro-pyrrolo[1,2-c]pyrimidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 85 percent / nBu₄NI; K₂CO₃ / acetonitrile

2.1: Me₃P; H₂O / tetrahydrofuran

3.1: iPr₂NEt / acetonitrile

4.1: pyridine; DMAP / CH₂Cl₂

5.1: NaN₃ / dimethylformamide / -15 °C

6.1: 74 percent / (NH₄)2Ce(NO₃)6 / CH₂Cl₂; 2-methyl-propan-2-ol

7.1: tBuOK

7.2: 70 percent / (Me₃Si)2NH

8.1: 95 percent / H₂O / acetonitrile / 70 °C

9.1: Me₃P; H₂O / tetrahydrofuran

10.1: AgNO₃; Et₃N / acetonitrile

11.1: tetrahydrofuran; acetonitrile / -78 °C

11.2: 82 percent / K₂CO₃ / methanol

12.1: 57 percent / OsCl₃; Na₂CO₃ / ethyl acetate; acetonitrile; H₂O

With pyridine; dmap; sodium azide; ammonium cerium(IV) nitrate; osmium (III) chloride; potassium tert-butylate; water; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja0608545