tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

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Chemical Name:tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate
CAS No.:870773-50-5
Molecular Formula:C₁₉H₂₇FN₂O₄
Molecular Weight:366.433
Hs Code.:

Synonyms:tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

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Chemical Property of tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

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Technology Process of tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

There total 11 articles about tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690257-93-3
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

: 870773-50-5
tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.08.049

Reference yield:

: 690257-82-0
(2R,3S)-2-azido-3-(4-bromophenyl)butanoic acid

: 870773-50-5
tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

2: triphenylphosphine / 1,4-dioxane; water / 12 h / 90 °C

3: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 20 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 14 h / 90 °C

5: sodium hydroxide; water; dihydrogen peroxide / 2 h / 0 °C

With sodium hydroxide; water; dihydrogen peroxide; potassium acetate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; dimethyl sulfoxide;

Reference yield:

: 705292-65-5
(2S,3S)-2-Amino-3-(4-bromo-phenyl)-1-((S)-3-fluoro-pyrrolidin-1-yl)-butan-1-one

: 870773-50-5
tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 14 h / 90 °C

3: sodium hydroxide; water; dihydrogen peroxide / 2 h / 0 °C

With sodium hydroxide; water; dihydrogen peroxide; potassium acetate; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; dimethyl sulfoxide;