2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

Base Information

Chemical Name:2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile
CAS No.:122376-88-9
Molecular Formula:C₂₃H₁₅F₂N₃O₂
Molecular Weight:403.388
Hs Code.:

Synonyms:2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

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Chemical Property of 2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

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Technology Process of 2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

There total 3 articles about 2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 122376-72-1
(3,5-Difluoro-phenyl)-pyridin-2-yl-acetonitrile

: 122376-88-9
2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1.) r.t., 1 h, 2.) 140 deg C, 5 h;
DOI:10.1002/ardp.19893220310

Reference yield:

: 109-09-1
2-chloropyridine

: 122376-88-9
2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / NaNH₂ / toluene

2: 65 percent / 1.) NaH / dimethylformamide / 1.) r.t., 1 h, 2.) 140 deg C, 5 h

With sodium hydride; sodium amide; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/ardp.19893220310

Reference yield:

: 122376-76-5
2-(3,5-difluorophenyl)acetonitrile

: 122376-88-9
2-(3,5-Difluoro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / NaNH₂ / toluene

2: 65 percent / 1.) NaH / dimethylformamide / 1.) r.t., 1 h, 2.) 140 deg C, 5 h

With sodium hydride; sodium amide; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/ardp.19893220310