2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Base Information

Chemical Name:2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide
CAS No.:1338346-38-5
Molecular Formula:C₂₉H₃₈ClN₅O₄Si
Molecular Weight:584.19
Hs Code.:

2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Synonyms:2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

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Chemical Property of 2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

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Technology Process of 2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

There total 7 articles about 2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1338346-17-0
2-[2-bromo-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

: 89694-47-3
(4-chloro-3-methoxyphenyl)boronic acid

: 1338346-38-5
2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 160 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1338346-38-5
2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 3 h / 60 °C

3: diisobutylaluminium hydride / toluene; tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

4: sodium hydrogensulfite / ethanol; water / 0.08 h / 150 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.5 h / 160 °C / Microwave irradiation

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diisobutylaluminium hydride; sodium carbonate; potassium carbonate; sodium hydrogensulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 216529-35-0
methyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate

: 1338346-38-5
2-[2-[4-chloro-3-(methyloxy)phenyl]-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazol-4-yl]-N,N-dimethyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 3 h / 60 °C

2: diisobutylaluminium hydride / toluene; tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

3: sodium hydrogensulfite / ethanol; water / 0.08 h / 150 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.5 h / 160 °C / Microwave irradiation

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diisobutylaluminium hydride; sodium carbonate; sodium hydrogensulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; toluene;