benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Base Information

Chemical Name:benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate
CAS No.:1381763-65-0
Molecular Formula:C₂₈H₃₈N₆O₅
Molecular Weight:538.647
Hs Code.:

Synonyms:benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

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Chemical Property of benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

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Technology Process of benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

There total 2 articles about benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 9-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-[[(propan-2-yl)amino]methyl]tetrahydro-2H-furano[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-amine

: benzyl 4-formylbutanoate

: 1381763-65-0
benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Guidance literature:: 9-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-[[(propan-2-yl)amino]methyl]tetrahydro-2H-furano[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-amine; benzyl 4-formylbutanoate; In methanol; dichloromethane; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In methanol; 1,2-dichloro-ethane;

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 1381763-65-0
benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydroxide / methanol / 2 h / Reflux

1.2: 2 h / 20 °C

2.1: 2-iodoxybenzoic acid / 2 h / Reflux

3.1: dichloromethane; methanol / 0.33 h / 20 °C

With 2-iodoxybenzoic acid; tetra(n-butyl)ammonium hydroxide; In methanol; dichloromethane;

Reference yield:

: 1381763-65-0
benzyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

: 1381763-17-2
N-(2-amino-4-fluoro-5-isopropylphenyl)-5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;