5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

Base Information

Chemical Name:5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide
CAS No.:1381763-69-4
Molecular Formula:C₂₈H₄₁N₇O₄
Molecular Weight:539.678
Hs Code.:

Synonyms:5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

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Chemical Property of 5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

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Technology Process of 5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

There total 9 articles about 5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1381763-68-3
5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

: 1381763-69-4
5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

Guidance literature:: 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide; With water; trifluoroacetic acid; at 20 ℃; for 1h;

With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 134848-96-7
benzyl 5-hydroxy pentanoate

: 1381763-69-4
5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-iodoxybenzoic acid / 2 h / Reflux

2.1: dichloromethane; methanol / 0.33 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: trifluoroacetic acid; water / 1 h / 20 °C

5.2: 0.5 h / 20 °C

With 2-iodoxybenzoic acid; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: benzyl 4-formylbutanoate

: 1381763-69-4
5-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)-N-(4-(tert-butyl)phenyl)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; methanol / 0.33 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: trifluoroacetic acid; water / 1 h / 20 °C

4.2: 0.5 h / 20 °C

With water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;