Technology Process of Boc-Orn(Z)-Phe-NMeBzl
There total 1 articles about Boc-Orn(Z)-Phe-NMeBzl which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; isobutyl chloroformate;
Yield given. Multistep reaction;
1.) CH2Cl2, -20 deg C, 20 min, 2.) CH2Cl2, from -35 deg C to 0 deg C, 2 h;
DOI:10.1021/jm00068a003
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 4N HCl / CH2Cl2; dioxane / 1.) 0 deg C, 1 h, 2.) RT, 1 h
2: HOBT, WSCD / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 3 h
3: 86.7 percent / 4N HCl, H2 / 5percent Pd/C / ethanol; tetrahydrofuran / 2 h / 760 Torr
With
hydrogenchloride; hydrogen; benzotriazol-1-ol;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00068a003
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4N HCl / CH2Cl2; dioxane / 1.) 0 deg C, 1 h, 2.) RT, 1 h
2: 88.2 percent / bis(trimethylsilyl)acetamide / CH2Cl2 / 2 h / 0 °C
3: 87 percent / H2, 4N HCl / 5percent Pd/C / ethanol; tetrahydrofuran / 0.07 h / 760 Torr
4: 61.8 percent / HOBT, WSCD / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h
5: 4N HCl / CH2Cl2; dioxane / 1.) 0 deg C, 15 min, 2.) RT, 0.5 h
6: triethylamine / dimethylformamide / 0.5 h / -15 °C
With
hydrogenchloride; hydrogen; benzotriazol-1-ol; bis-(trimethylsilyl)acetamide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00068a003
