4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide

Base Information

Chemical Name:4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
CAS No.:372152-24-4
Molecular Formula:C₂₁H₂₉N₅O₄S
Molecular Weight:447.558
Hs Code.:

Synonyms:4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide

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Chemical Property of 4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide

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Technology Process of 4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide

There total 2 articles about 4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147676-70-8
5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one

: 109-89-7
diethylamine

: 372152-24-4
4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide

Guidance literature:: 5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one; With 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; In dimethyl sulfoxide; at 70 ℃; for 3h; Inert atmosphere; Microwave irradiation;

With N-chloro-succinimide; In tetrahydrofuran; at 23 ℃; for 1.5h; Inert atmosphere;

diethylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 23 ℃; for 20h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/ol403072r

Reference yield:

: 139756-21-1
5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

: 372152-24-4
4-ethoxy-N,N-diethyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium bromide; Oxone / water; acetone / 2 h / 23 °C

2.1: potassium pyrosulfite; sodium formate; palladium diacetate; triphenylphosphine; 1,10-Phenanthroline; tetraethylammonium bromide / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere; Microwave irradiation

2.2: 1.5 h / 23 °C / Inert atmosphere

2.3: 20 h / 23 °C / Inert atmosphere

With Oxone; 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; potassium bromide; In water; dimethyl sulfoxide; acetone;
DOI:10.1021/ol403072r