3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

Base Information

Chemical Name:3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline
CAS No.:1268468-60-5
Molecular Formula:C₂₁H₂₁NO₂S
Molecular Weight:351.469
Hs Code.:

Synonyms:3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

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Chemical Property of 3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

Chemical Property:

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Technology Process of 3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

There total 4 articles about 3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268468-59-2
3-iodo-4-(2-methyltetrahydrofuran-3-ylsulfanyl)quinoline

: 5720-07-0
4-methoxyphenylboronic acid

: 1268468-60-5
3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 90 ℃; for 16h;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1268468-60-5
3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide; sodium hydroxide; iodine / water / 3 h / 20 °C

2: trichlorophosphate / 2 h / 90 °C

3: caesium carbonate / 1,4-dioxane; tetrahydrofuran / 20 - 90 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 90 °C

With iodine; sodium carbonate; caesium carbonate; potassium iodide; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; 4: Suzuki Coupling;

Reference yield:

: 590371-90-7
4-chloro-3-iodoquinoline

: 1268468-60-5
3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 1,4-dioxane; tetrahydrofuran / 20 - 90 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 90 °C

With sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; 2: Suzuki Coupling;