Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

Base Information

Chemical Name:Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate
CAS No.:1201147-24-1
Molecular Formula:C₂₅H₂₇N₃O₅
Molecular Weight:449.506
Hs Code.:

Synonyms:Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

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Chemical Property of Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

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Technology Process of Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

There total 3 articles about Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201647-74-6,1372860-36-0
ethyl 3-{7-[(Z)-(hydroxyimino)(amino)methyl]-1H-indol-3-yl}propanoate

: 5409-31-4
3,4-diethoxybenzoic acid

: 1201147-24-1
Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

Guidance literature:: 3,4-diethoxybenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 2h;

ethyl 3-{7-[(Z)-(hydroxyimino)(amino)methyl]-1H-indol-3-yl}propanoate; In tetrahydrofuran; at 60 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 130 ℃; for 3h;

Reference yield:

: 1201146-58-8
ethyl 3-(7-cyano-1H-indol-3-yl)propanoate

: 1201147-24-1
Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol

2: tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran

With hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2012.02.083

Reference yield:

: 1201647-74-6,1372860-36-0
C₁₄H₁₇N₃O₃

: 5409-31-4
3,4-diethoxybenzoic acid

: 1201147-24-1
Ethyl 3-(7-{5-[3,4-bis(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate

Guidance literature:: With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.02.083