5409-31-4Relevant academic research and scientific papers
HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
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, (2015/11/10)
Provided herein are novel heteroaromatic derivatives, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a prodrug, a pharmaceutically acceptable salt or a prodrug thereof, and pharmaceutical compositions containing such compounds. Also provided herein are uses of such compounds or pharmaceutical compositions thereof in the manufacture of a medicament for treating respiratory diseases, especially chronic obstructive pulmonary disease (COPD).
Exquisite synthesis of a designed PAR-1 antagonist
Miao, Hua-Ming,Zhao, Gui-Long,Zhang, Lin-Shan,Shao, Hua,Wang, Jian-Wu
experimental part, p. 1981 - 1993 (2012/01/04)
The synthesis of a designed, sterically congested geminal dimethyl-bearing PAR-1 antagonist was achieved by a route of ten steps, with the oxidation of an electron-rich benzaldehyde, the construction of a tertiary alkyl azide, and the selective hydrogenolysis of a 1,5-fused tetrazole to generate the cyclic amidine with Raney-Ni being the key steps. The selective hydrogenolysis of 1,5-fused tetrazole to generate the cyclic amidine with Raney-Ni was discovered and may be generally used for the synthesis of structurally unusual cyclic amidines. Several unsuccessful attempts to construct the desired geminal dimethyl-bearing cyclic amidine were also discussed. Copyright
Quinazoline derivatives and therapeutic use thereof
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Page/Page column 18, (2008/06/13)
Quinazoline derivatives represented by the general formula pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for using the compounds for treatment of hyperproliferative disorders are also described.
The synthesis and mesomorphism of di-, tetra- and hexa-catenar liquid crystals based on 2,2′-bipyridine
Rowe, Kathryn E.,Bruce, Duncan W.
, p. 331 - 341 (2007/10/03)
2,2′-Bipyridines are known to coordinate to a wide variety of metal centres. In this paper, liquid-crystalline two-chained (dicatenar), four-chained (tetracatenar) and six-chained (hexacatenar) bipyridines are synthesised and their mesomorphism is described. For the tetracatenar bipyridines, a full homologous series, from tetramethoxy to tetratetradecyloxy, was synthesised, and the phase diagram showed a classic progression from nematic and smectic C phases at short chain length, through a cubic phase to a columnar phase.
Influence of lateral alkoxy substitution on mesomorphic properties of copper complexes
Berdague, Philippe,Perez, Felix,Courtieu, Jacques,Bayle, Jean-Pierre
, p. 335 - 343 (2007/10/02)
Coordination complexes between copper and some lateral alkoxy chain-substituted N-(4-(4'-alkoxybenzoyloxy)salicylidene)-4-n-butylaniline have been synthesized.The lateral chain was introduced on the outer ring bearing the ester function.In the case of a 3,4-disubstitution, the mesomorphic behavior is related to the number of carbons in the terminal chain.If this is too small, the mesomorphic properties of the complexes disappear.In contrast, copper complexes are liquid crystalline and show more ordered phases by comparison with the free ligand.In case of a 2,4-disubstitution, the phases are nematic and the clearing temperatures are near room temperature, but the observed phases are essentially monotropic for the ligands, as well as for the complexes.Keywords: nematic / copper complex / lateral substitution / Schiff base
