trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

Base Information

Chemical Name:trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol
CAS No.:1365838-48-7
Molecular Formula:C₁₈H₂₂N₆O₂S
Molecular Weight:386.478
Hs Code.:

Synonyms:trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

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Chemical Property of trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

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Technology Process of trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

There total 6 articles about trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1365838-40-9
N-[6-[(methyloxy)methyl]-2-(methylsulfonyl)-4-pyrimidinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 1365838-48-7
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

Guidance literature:: In isopropyl alcohol; at 150 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: 1365838-39-6
N-[6-[(methyloxy)methyl]-2-(methylthio)-4-pyrimidinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: 1365838-48-7
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / N,N-dimethyl-formamide / 20 °C

2: isopropyl alcohol / 0.75 h / 150 °C / Microwave irradiation

With Oxone; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 412923-40-1
2-bromothiazolo[5,4-b]pyridine

: 1365838-48-7
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 - 40 °C / Inert atmosphere

2.1: Oxone / N,N-dimethyl-formamide / 20 °C

3.1: isopropyl alcohol / 0.75 h / 150 °C / Microwave irradiation

With Oxone; sodium hydride; In N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;