trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

Base Information

Chemical Name:trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate
CAS No.:1365837-23-5
Molecular Formula:C₁₉H₂₄N₆O₄S₂
Molecular Weight:464.569
Hs Code.:

Synonyms:trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

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Chemical Property of trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

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Technology Process of trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

There total 7 articles about trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1365838-48-7
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexanol

: 124-63-0
methanesulfonyl chloride

: 1365837-23-5
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 412923-40-1
2-bromothiazolo[5,4-b]pyridine

: 1365837-23-5
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 - 40 °C / Inert atmosphere

2.1: Oxone / N,N-dimethyl-formamide / 20 °C

3.1: isopropyl alcohol / 0.75 h / 150 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With Oxone; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 68087-13-8
6-[(methyloxy)methyl]-2-(methylthio)-4(1H)-pyrimidinone

: 1365837-23-5
trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; tert-Octylamine / acetonitrile / 7 h / Reflux

2.2: 5 h / 20 - 50 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

3.2: 0 - 40 °C / Inert atmosphere

4.1: Oxone / N,N-dimethyl-formamide / 20 °C

5.1: isopropyl alcohol / 0.75 h / 150 °C / Microwave irradiation

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With Oxone; tert-Octylamine; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; mineral oil;