N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

Base Information

Chemical Name:N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide
CAS No.:881417-04-5
Molecular Formula:C₃₀H₃₂N₂O₆S
Molecular Weight:548.66
Hs Code.:

Synonyms:N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

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Chemical Property of N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

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Technology Process of N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

There total 10 articles about N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 881417-04-5
N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 15 h / 20 °C

2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

3: 72 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 1.5 h / 20 °C

4: PtO₂; H₂ / ethyl acetate / 3 h / 20 °C

5: 429 mg / pyridine / CH₂Cl₂ / 3 h / Heating

With pyridine; platinum(IV) oxide; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; ethyl acetate; 3: Mitsunobu reaction;
DOI:10.3987/COM-05-S(K)58

Reference yield:

: 881416-99-5
2-(1-tert-butyldimethylsilylbut-3-enyl)nitrobenzene

: 881417-04-5
N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: BH₃*THF / tetrahydrofuran / 7 h / 0 °C

2: 21.5 g / H₂O₂; NaOH / H₂O / 0 - 20 °C

3: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 15 h / 20 °C

4: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

5: 72 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 1.5 h / 20 °C

6: PtO₂; H₂ / ethyl acetate / 3 h / 20 °C

7: 429 mg / pyridine / CH₂Cl₂ / 3 h / Heating

With pyridine; platinum(IV) oxide; sodium hydroxide; borane-THF; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 5: Mitsunobu reaction;
DOI:10.3987/COM-05-S(K)58

Reference yield:

: 881417-00-1
2-(1-tert-butyldimethylsilyloxy-4-hydroxybutyl)nitrobenzene

: 881417-04-5
N-{2-[1-(N-phthalimidoyl)-4-(tetrahydropyran-2-yloxy)butyl]phenyl}-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 15 h / 20 °C

2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

3: 72 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 1.5 h / 20 °C

4: PtO₂; H₂ / ethyl acetate / 3 h / 20 °C

5: 429 mg / pyridine / CH₂Cl₂ / 3 h / Heating

With pyridine; platinum(IV) oxide; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; ethyl acetate; 3: Mitsunobu reaction;
DOI:10.3987/COM-05-S(K)58