methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate

Base Information

• Chemical Name: methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate
• CAS No.: 247035-44-5
• Molecular Formula: C₁₅H₂₁NO₆S
• Molecular Weight: 343.401
• Mol file: 247035-44-5.mol

Synonyms:methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate

Chemical Property of methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate

There total 11 articles about methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(4-hydroxypiperidin-1-yl)-3-methoxybenzoate (247035-42-3) + methanesulfonyl chloride (124-63-0) → methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate (247035-44-5)

Guidance literature:

With triethylamine; In dichloromethane; for 1h;

DOI:10.1016/j.bmc.2005.10.061

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate (247035-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / dimethylsulfoxide / 72 h / 120 °C

2: Et₃N / CH₂Cl₂ / 1 h

With triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2005.10.061

Reference yield:

methyl 4-fluoro-3-methoxy-benzoate (74385-37-8) → methyl 4-{4-(methanesulfonyloxy)piperidin-1-yl}-3-methoxybenzoate (247035-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / dimethylsulfoxide / 72 h / 120 °C

2: Et₃N / CH₂Cl₂ / 1 h

With triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2005.10.061

upstream raw materials:

methyl 4-(4-hydroxypiperidin-1-yl)-3-methoxybenzoate

methanesulfonyl chloride

4-HYDROXYPIPERIDINE

methyl 4-fluoro-3-methoxy-benzoate

Downstream raw materials:

methyl 4-(4-aminopiperidin-1-yl)-3-methoxybenzoate

methyl 3-methoxy-4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoate

3-methoxy-4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid

(2S)-benzenesulfonylamino-3-[3-hydroxy-4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionic acid