benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

• Chemical Name: benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate
• CAS No.: 1227610-24-3
• Molecular Formula: C₂₆H₃₇N₃O₃
• Molecular Weight: 439.598
• Mol file: 1227610-24-3.mol

Synonyms:benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property of benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate

There total 7 articles about benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.86%

1-cyclobutyl[1,4]diazepane + 7-(benzyloxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid (1227610-19-6) → benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate (1227610-24-3)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h;

Reference yield:

1-cyclobutyl[1,4]diazepane + benzyl 2-(chlorocarbonyl)-7-azaspiro[3.5]nonane-7-carboxylate (1227610-44-7) → benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate (1227610-24-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jm4014828

Reference yield:

benzyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate (1227610-18-5) → benzyl 2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate (1227610-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hypochlorite; sodium hydrogencarbonate; sodium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl / dichloromethane; water / 2 h

2: oxalyl dichloride / dichloromethane / 4 h / 0 - 15 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; oxalyl dichloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium bromide; In dichloromethane; water;

DOI:10.1021/jm4014828

upstream raw materials:

7-(benzyloxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid

benzyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

benzyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

benzyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate

Downstream raw materials:

(7-benzoyl-7-azaspiro[3.5]nonan-2-yl)(4-cyclobutyl-1,4-diazepan-1-yl)methanone