Technology Process of Methyl 3-formyl-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropanoate
There total 9 articles about Methyl 3-formyl-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / Br2, HOAc / 1 h / Ambient temperature
2: 98 percent / pyrrolidine / pyridine / 6 h / 100 °C
3: 1) CuSO4*H2O, NH4OH, NH2OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h
4: 92 percent / H2 / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature
5: 1) KCl, HCl(g) / 1) Et2O, 0 deg C, 2) GH2O, EtOH, 50 deg C, 30 min
With
pyrrolidine; pyridine; hydrogenchloride; ammonium hydroxide; potassium chloride; hydroxylamine hydrochloride; hydrogen; bromine; copper(II) sulfate; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine;
DOI:10.1021/jo00052a046
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 63 percent / POCl3 / 1) 0 deg C, 20 min, 2) 65 deg C, 10 h
2: 79 percent / NaOH / H2O; dioxane / 2 h / 80 °C
3: 1) CuSO4*H2O, NH4OH, NH2OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h
4: 92 percent / H2 / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature
5: 1) KCl, HCl(g) / 1) Et2O, 0 deg C, 2) GH2O, EtOH, 50 deg C, 30 min
With
pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; potassium chloride; hydroxylamine hydrochloride; hydrogen; copper(II) sulfate; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo00052a046
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / pyrrolidine / pyridine / 6 h / 100 °C
2: 1) CuSO4*H2O, NH4OH, NH2OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h
3: 92 percent / H2 / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature
4: 1) KCl, HCl(g) / 1) Et2O, 0 deg C, 2) GH2O, EtOH, 50 deg C, 30 min
With
pyrrolidine; pyridine; hydrogenchloride; ammonium hydroxide; potassium chloride; hydroxylamine hydrochloride; hydrogen; copper(II) sulfate;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine;
DOI:10.1021/jo00052a046