Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate

Base Information

• Chemical Name: Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate
• CAS No.: 279690-85-6
• Molecular Formula: C₂₄H₂₆NO₄P
• Molecular Weight: 423.448
• Mol file: 279690-85-6.mol

Synonyms:Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate

Chemical Property of Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate

There total 2 articles about Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Dimethyl phosphite (868-85-9) + (2S*,3S*)-2-benzoyl-1-benzyl-3-(phenyl)azidridine (6372-57-2,6476-12-6,72997-93-4) → Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate (279690-85-6)

Guidance literature:

In benzene; for 4h; Heating;

DOI:10.1039/a909521g

Reference yield:

2,3-dibromo-1,3-diphenylpropane-1-one (611-91-6) → Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate (279690-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / benzene / 20 h / 20 °C

2: 90 percent / benzene / 4 h / Heating

In benzene; 1: Substitution / 2: Addition;

DOI:10.1039/a909521g

Reference yield:

Dimethyl N-benzyl-N-(2-oxo-2-phenylethyl)amino-1-phenylmethylphosphonate (279690-85-6) → [(S)-((R)-2-Hydroxy-2-phenyl-ethylamino)-phenyl-methyl]-phosphonic acid dimethyl ester + [(S)-((S)-2-Hydroxy-2-phenyl-ethylamino)-phenyl-methyl]-phosphonic acid dimethyl ester

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 24h; Title compound not separated from byproducts.;

DOI:10.1039/a909521g

upstream raw materials:

Dimethyl phosphite

(2S*,3S*)-2-benzoyl-1-benzyl-3-(phenyl)azidridine

2,3-dibromo-1,3-diphenylpropane-1-one