(1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester
CAS No.:188472-65-3
Molecular Formula:C₂₆H₃₈O₅SeSi₂
Molecular Weight:565.716
Hs Code.:

Synonyms:(1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of (1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

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Technology Process of (1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

There total 4 articles about (1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5707-04-0
Phenylselenyl chloride

: 188472-64-2
(1R,6S)-3-Methyl-6-(2-trimethylsilanyl-furan-3-yl)-4,6-bis-trimethylsilanyloxy-cyclohex-3-enecarboxylic acid ethyl ester

: 188472-65-3
(1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: In tetrahydrofuran;
DOI:10.1039/a605894i

Reference yield:

: 129312-19-2
Ethyl (1R,2S,4S,5S)-2,4-dihydroxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate

: 188472-65-3
(1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMSO, oxalyl chloride, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) -78 deg C, 15 min; -78 deg C to r.t., 1 h

2: 85 percent / NEt₃ / CCl₄

3: 82 percent / tetrahydrofuran

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; tetrachloromethane;
DOI:10.1039/a605894i

Reference yield:

: 129313-41-3
Ethyl (1R,2S,4S,5S)-2-hydroxy-4-<(2S)-2-hydroxy-2-phenylacetoxy>-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate

: 188472-65-3
(1R,2S,5R)-5-Methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-2-trimethylsilanyloxy-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃ / ethanol / 16 h / Ambient temperature

2: 1.) DMSO, oxalyl chloride, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) -78 deg C, 15 min; -78 deg C to r.t., 1 h

3: 85 percent / NEt₃ / CCl₄

4: 82 percent / tetrahydrofuran

With oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1039/a605894i