N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

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Chemical Name:N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide
CAS No.:1089669-64-6
Molecular Formula:C₂₀H₁₈F₂N₄O₄S₃
Molecular Weight:512.582
Hs Code.:

Synonyms:N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

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Chemical Property of N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

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Technology Process of N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

There total 9 articles about N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₆F₂N₄O₆S₃

: 1089669-64-6
N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

Guidance literature:: With trifluoroacetic acid; for 0.5h;

Reference yield:

: 1014613-45-6
[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]boronic acid

: 1089669-64-6
N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

2.1: methyl trifluoromethanesulfonate / tetrahydrofuran / 0.5 h / 0 °C

2.2: 20 °C

3.1: trifluoroacetic acid / 0.5 h

With sodium carbonate; trifluoroacetic acid; methyl trifluoromethanesulfonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: C₂₀H₂₃BF₂N₂O₄S

: 1089669-64-6
N-(2-aminoethyl)-5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / tetrahydrofuran; hexanes / 0.17 h / -78 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

3.1: methyl trifluoromethanesulfonate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 20 °C

4.1: trifluoroacetic acid / 0.5 h

With hydrogenchloride; water; sodium carbonate; trifluoroacetic acid; methyl trifluoromethanesulfonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; hexanes; water;