Technology Process of (1'S,4'R)-1-[2',3'-dideoxy-β-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone
There total 10 articles about (1'S,4'R)-1-[2',3'-dideoxy-β-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 72h;
DOI:10.1021/jm0504306
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 950 mg / TMSOTf / 1,2-dichloro-ethane / 18 h / 20 °C
2: 100 percent / TBAF / tetrahydrofuran / 72 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/jm0504306
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / aq. NaOH / methanol / 16 h / Heating
2: 58 percent / aq. NH3 / ethanol / 16 h / Heating
3: ammonium sulfate / 2 h / Heating
4: 950 mg / TMSOTf / 1,2-dichloro-ethane / 18 h / 20 °C
5: 100 percent / TBAF / tetrahydrofuran / 72 h / 20 °C
With
ammonium hydroxide; sodium hydroxide; ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jm0504306