Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

Base Information

Chemical Name:Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester
CAS No.:790302-03-3
Molecular Formula:C₁₇H₂₁N₃O₅
Molecular Weight:347.371
Hs Code.:

Synonyms:Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

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Chemical Property of Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

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Technology Process of Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

There total 4 articles about Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 52192-32-2
(S)-6-acetoxy-2-(benzyloxycarbonyl)aminohexanoic acid

: 790302-03-3
Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

Guidance literature:: (S)-6-acetoxy-2-(benzyloxycarbonyl)aminohexanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -25 - -10 ℃; for 1h;

diazomethane; In tetrahydrofuran; diethyl ether; at -10 - 20 ℃;
DOI:10.1021/ol048437p

Reference yield:

: 2212-75-1
N₂-[(benzyloxy)carbonyl]-L-lysine

: 790302-03-3
Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaNO₂; AcOH / 6 h / 40 °C

2.1: Et₃N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C

2.2: 70 percent / tetrahydrofuran; diethyl ether / -10 - 20 °C

With acetic acid; triethylamine; sodium nitrite; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1021/ol048437p

Reference yield:

: 14511-39-8
2(S)-2-amino-6-(benzylideneamino)hexanoic acid

: 790302-03-3
Acetic acid (S)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C

1.2: HCl / ethanol / 0.17 h / 50 °C

2.1: NaNO₂; AcOH / 6 h / 40 °C

3.1: Et₃N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C

3.2: 70 percent / tetrahydrofuran; diethyl ether / -10 - 20 °C

With sodium hydroxide; acetic acid; triethylamine; sodium nitrite; isobutyl chloroformate; In tetrahydrofuran; ethanol;
DOI:10.1021/ol048437p