Technology Process of (4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane
There total 9 articles about (4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium hexamethylsilazane / tetrahydrofuran / 1.5 h / 78 °C
2: palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate / ethyl acetate / 1.5 h
3: lithium hydroxide pentahydrate; water / tetrahydrofuran / 4 h / 0 - 20 °C
4: tetrachloromethane; sodium hydrogencarbonate; triphenylphosphine / 48 h / Reflux
5: ammonia; lithium; ferric nitrate / 2 h / -40 °C
6: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C
7: methanol; potassium carbonate / 0.5 h / 0 °C
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
With
methanol; tetrachloromethane; palladium 10% on activated carbon; lithium hydroxide pentahydrate; ammonia; water; hydrogen; lithium; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; ferric nitrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
1: Julia Olefin synthesis / 6: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2011.10.117
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C
2: methanol; potassium carbonate / 0.5 h / 0 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
With
methanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
1: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2011.10.117
