(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:1353667-10-3
Molecular Formula:C₄₉H₈₁NO₁₀
Molecular Weight:844.183
Hs Code.:

(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Synonyms:(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of (S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of (S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 16 articles about (S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1353667-08-9
(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

: 1353667-18-1
C₂₉H₅₆N₂O₆

: 1353667-10-3
(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 1.5h;
DOI:10.1016/j.tetlet.2011.10.117

Reference yield:

: 1353667-14-7
C₂₀H₂₉ClO₄

: 1353667-10-3
(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia; lithium; ferric nitrate / 2 h / -40 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

3: methanol; potassium carbonate / 0.5 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

5: n-butyllithium / tetrahydrofuran / 1.5 h / -78 - 0 °C

With methanol; n-butyllithium; ammonia; lithium; potassium carbonate; ferric nitrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2011.10.117

Reference yield:

: C₂₇H₃₁NO₇

: 1353667-10-3
(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; potassium carbonate / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

3: n-butyllithium / tetrahydrofuran / 1.5 h / -78 - 0 °C

With methanol; n-butyllithium; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2011.10.117