(E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

Base Information

Chemical Name:(E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol
CAS No.:1315477-86-1
Molecular Formula:C₂₆H₂₀INO₃S
Molecular Weight:553.42
Hs Code.:

Synonyms:(E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

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Chemical Property of (E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

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Technology Process of (E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

There total 4 articles about (E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1315477-46-3
1-phenyl-1-(2-(tosylamino)naphthalen-3-yl)prop-2-yn-1-ol

: 1315477-86-1
(E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

Guidance literature:: With N-iodo-succinimide; 2-(dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl Au bis(trifluoromethylsulfonyl)imide; In acetone; at 20 ℃; for 0.25h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo201208e

Reference yield:

: C₂₄H₁₉NO₃S

: 1315477-86-1
(E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 3 h / Reflux; Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere; Saturated solution

2.1: N-iodo-succinimide; 2-(dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl Au bis(trifluoromethylsulfonyl)imide / acetone / 0.25 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; 2-(dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl Au bis(trifluoromethylsulfonyl)imide; In tetrahydrofuran; acetone;
DOI:10.1021/jo201208e

Reference yield:

: 55270-95-6
(3-aminonaphthalen-2-yl)(phenyl)methanone

: 1315477-86-1
(E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 4 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 3 h / Reflux; Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere; Saturated solution

3.1: N-iodo-succinimide; 2-(dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl Au bis(trifluoromethylsulfonyl)imide / acetone / 0.25 h / 20 °C / Inert atmosphere

With pyridine; N-iodo-succinimide; 2-(dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl Au bis(trifluoromethylsulfonyl)imide; In tetrahydrofuran; acetone;
DOI:10.1021/jo201208e