55270-95-6

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 141281-58-5 3-Amino-2-(hydroxymethyl)naphthalene 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 16673-86-2 2-methyl-4H-naphth<2,3-d><1,3>oxazin-4-one 
• 591-51-5 phenyllithium 
• 156753-34-3 (2-acetamidonaphthalen-3-yl)phenylmethanone 

Downstream Products

• 1388038-71-8 3-phenyl-2-(phenylethynyl)-1-tosyl-1H-benzo[f]indole 
• 1315477-46-3 1-phenyl-1-(2-(tosylamino)naphthalen-3-yl)prop-2-yn-1-ol 
• 1315477-86-1 (E)-2-(iodomethylene)-3-phenyl-1-tosyl-2,3-dihydro-1H-benzo[f]indol-3-ol 
• 1315477-62-3 3-phenyl-1-tosyl-1H-benzo[f]indole-2-carbaldehyde 
• 1334483-39-4 5-phenyl-1-tosyl-2,3-dihydro-1H-naphtho[2,3-b]azepine 
• 1334483-30-5 1-cyclopropyl-1-(2-(tosylamino)-3-naphthalenyl)(phenyl)methanol 
• 4025-05-2 1-methyl-5-phenyl-1,3-dihydronaphtho<2,3-e><1,4>diazepin-2-one 
• 4025-00-7 5-phenyl-1,3-dihydronaphtho<2,3-e><1,4>diazepin-2-one 

Relevant academic research and scientific papers

Synthesis of benzo[g]quinoline derivatives and their electroluminescent properties

Two fluorescent benzo[g]quinoline derivatives were synthesized via Friedl?nder synthesis. Multilayered OLEDs using benzo[g]quinoline derivatives as the emitters showed unexpected emissions by electroplexes. Particularly, a device using 2-(naphthalen-3-yl)

Direct Triple Annulations: A Way to Design Large Triazastarphenes with Intertwined Hexagonal Packing

A new straightforward synthetic strategy has been elaborated to achieve star-shaped triazatrinaphthylene and, for the first time, triazatrianthrylene derivatives. Their solution- and solid-state properties were thoroughly characterized by cyclic voltammetry, UV–vis absorption spectroscopy, X-ray diffraction, and density functional theory calculations. Original hexagonal molecular arrangements were found in the crystal phase, which opens a new pathway for designing materials with improved three-dimensional charge-transport properties.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents

Estrogens play undisputedly important physiological roles, but lifetime exposure to estrogens has also been linked to the development of breast cancer. Moreover, imbalanced estrogen levels have been associated with various symptoms such as osteoporosis and menopausal disorders. For the improvement of such estrogen imbalances, estrogenic reagents with regulatory properties have shown promising potential. Herein, we report the construction of a 12-arylbenzoacridine library via a diversity-oriented strategy that furnished non-toxic estrogenic and anti-estrogenic agents. Derivatives with a hydroxy group at the molecular edge exhibit potent binding affinity to the estrogen receptor α (ERα) and ERβ (IC50 μM), while binding to the estrogen-related receptor γ (ERRγ), i.e., an orphan nuclear receptor on which estrogens often trigger unfavorable events, was not observed. These findings offer valuable insights into 12-arylbenzoacridines as a novel platform for the development of selective estrogen-receptor modulators (SERMs).

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

The diversity-oriented doubling strategy, which generates two 12-arylbenzoacridines from a single triarylmethanol precursor was developed to construct a library of drug candidates for the identification of biologically active compounds. Exploration of this 12-arylbenzoacridine library furnished a 4′-OH derivative as an estrogenic compound.

Synthesis of Benzo-Fused Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors

The synthesis and in vitro evaluation of benzo-fused benzodiazepines 1-6 are described.These "molecular yardsticks" were employed to probe the spatial dimensions of the lipophilic pocket L2 in the benzodiazepine receptor (BzR) cleft and to dete

Pyrolysis of Aryl Azides. XII. Mechanistic Implications of the Very Small Neighbouring Group Effects Across the 2,3-Bond of 2-Azidonaphthalene

2-Azidonaphthalenes with nitro, acetyl, benzoyl and methoxycarbonyl substituents in the 3-position have been synthesized and then pyrolysed in nitrobenzene solution.At 120 deg C, the rates (relative to 2-azidonaphthalene) are respectively 27.9, 24.8, 5.00

The Regiospecific Synthesis Of Ortho Aminonaphthophenones Via The Addition Of Carbanions To Naphthoxazin-4-Ones

The conversion of nitronaphthalenes (see 4a and 4b) into the corresponding ortho aminonaphthylnitriles (5a and 5b) via the process of Tomioka, when combined with the addition of carbanions to the intermediate naphthoxazin-4-ones, provided a route to ortho aminonaphthophenones (7a) and (7b).These key intermediates were employed to synthesize the benzfused 2'-fluoro-1,4-benzodiazepines (1-3).