tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

Base Information

Chemical Name:tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate
CAS No.:1613465-81-8
Molecular Formula:C₂₅H₃₁N₅O₅
Molecular Weight:481.552
Hs Code.:

Synonyms:tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

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Chemical Property of tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

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Technology Process of tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

There total 3 articles about tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1588407-78-6
ethyl (2-(methylamino)ethyl)carbamate tert-butyl ester

: 52692-81-6
2-(chloromethyl)-6-nitro-3-phenylquinazolin-4(3H)-one

: 1613465-81-8
tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 80 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 616-79-5
2-amino-5-nitro-benzoic acid

: 1613465-81-8
tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

3: potassium carbonate; potassium iodide / acetonitrile / 0.17 h / 80 °C / Microwave irradiation

With potassium carbonate; triethylamine; potassium iodide; trichlorophosphate; In dichloromethane; acetonitrile;

Reference yield:

: 135590-27-1
2-(2-chloroacetamido)-5-nitrobenzoic acid

: 1613465-81-8
tert-butyl ethyl(2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 150 °C / Inert atmosphere; Microwave irradiation

2: potassium iodide; potassium carbonate / acetonitrile / 80 °C / Microwave irradiation

With potassium carbonate; potassium iodide; trichlorophosphate; In acetonitrile;
DOI:10.1021/jm501203v