(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

Base Information

Chemical Name:(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn
CAS No.:141806-31-7
Molecular Formula:C₄₈H₇₁N₇O₁₄
Molecular Weight:970.13
Hs Code.:

Synonyms:(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

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Chemical Property of (2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

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Technology Process of (2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

There total 4 articles about (2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 141806-30-6
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

: 141806-31-7
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00093a018

Reference yield:

: Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn TFA salt

: 141806-31-7
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2 N NaOH, 2.) Et₃N, hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) water, t-butanol, 2.) DMF, 0 deg C

2: 90.5 percent / 1 N NaOH / methanol

3: 83 percent / H₂ / 10percent Pd/C / methanol

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00093a018

Reference yield:

: 141806-29-3
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

: 141806-31-7
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

Guidance literature:: Multi-step reaction with 2 steps

1: 90.5 percent / 1 N NaOH / methanol

2: 83 percent / H₂ / 10percent Pd/C / methanol

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00093a018