(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

Base Information

Chemical Name:(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn
CAS No.:141806-29-3
Molecular Formula:C₅₇H₇₉N₇O₁₆
Molecular Weight:1118.29
Hs Code.:

Synonyms:(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

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Chemical Property of (2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

Chemical Property:

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Technology Process of (2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

There total 1 articles about (2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn TFA salt

: 111002-66-5
(2S,3S,4S)-3-hydroxy-4-methylproline methyl ester hydrochloride

: 141806-29-3
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

Guidance literature:: With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Yield given. Multistep reaction; 1.) water, t-butanol, 2.) DMF, 0 deg C;
DOI:10.1021/jm00093a018

Reference yield:

: 141806-29-3
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

: 141806-32-8
cyclo-(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

Guidance literature:: Multi-step reaction with 3 steps

1: 90.5 percent / 1 N NaOH / methanol

2: 83 percent / H₂ / 10percent Pd/C / methanol

3: 38 percent / diphenyl phosphorazidate (DPPA), NaHCO₃ / dimethylformamide / 9 h / 0 °C

With sodium hydroxide; diphenyl phosphoryl azide; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00093a018

Reference yield:

: 141806-29-3
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-OMe-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-δ-CBZ-Orn

: 141806-31-7
(2S,3S,4S)-3-hydroxy-4-methyl-Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(octyloxybenzoyl)-Orn

Guidance literature:: Multi-step reaction with 2 steps

1: 90.5 percent / 1 N NaOH / methanol

2: 83 percent / H₂ / 10percent Pd/C / methanol

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00093a018