1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

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Chemical Name:1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate
CAS No.:1337533-12-6
Molecular Formula:C₃₁H₃₄N₆O₃
Molecular Weight:538.649
Hs Code.:

Synonyms:1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

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Technology Process of 1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

There total 5 articles about 1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.3%

: 1337533-11-5
1,1-dimethylethyl 3-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

: 1337532-98-5
1-[(3-methylphenyl)acetyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole

: 1337533-12-6
1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 120 ℃; Microwave irradiation;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1337533-12-6
1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 - 60 °C

2: ammonium hydroxide / 2 h / 100 °C / Microwave irradiation

3: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 120 °C / Microwave irradiation

With ammonium hydroxide; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1337533-12-6
1,1-dimethylethyl 3-(4-amino-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / chloroform / 3 h / 20 - 70 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 - 60 °C

3: ammonium hydroxide / 2 h / 100 °C / Microwave irradiation

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 120 °C / Microwave irradiation

With ammonium hydroxide; N-Bromosuccinimide; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; chloroform;